[Bacteriology of leprosy].
نویسنده
چکیده
In a previous communication (2) a description of an acid-fast organism isolated from human and rat leprous lesions was reported! Embryonic chick tissue-cultures were used as the isolation medium. Later reports (3,4,5) have dealt with the influence of various environmental factors on the tinctorial characteristics of the organisms that were isolated. The present communication deals with results obtained in work done at the United States Marine Hospital, Carville, Louisiana. The same media as reported in the first paper of the series were employed, namely, embryonic chick tissue cultures, minced chick embryo medium, and glycerin veal agar slants. In addition, the above methods were paralleled by the procedure recommended by McKinley and Soule (1), employing glycerin veal agar slants kept under a gaseous environment of 40 percent oxygen, 10 percent carbon dioxide and 50 percent nitrogen. The purpose of the work was to determine whether or not the same organism could be isolated repeatedly by the method outlined in the first report of this series. A satisfactory experimental animal for human leprosy is not available, but if the same organism can be isolated repeatedly in pure culture, that may be indirect evidence that the cultured form is the true etiological agent of leprosy. There is considerable doubt in the minds of many workers that a satisfactory experimental animal would determine whether or not the isolated organism is the true agent of the disease. It is known that if rat granuloma is kept in the laboratory for several weeks and then injected into young normal rats, it is unable to produce rat leprosy. In other words, the material must be injected into new
منابع مشابه
Elimination of the acid fastness but not the gram positivity of leprosy bacilli after extraction with pyridine.
Bacilli from a number of tissues excised from cases of lepromatous and borderline leprosy, unlike mycobacteria, were found to lose their acid-fastness after treatment with pyridine.
متن کاملChemical characterization of organisms isolated from leprosy patients.
CHEMICAL ANALYSES OF THE CELL WALLS OF ORGANISMS ISOLATED IN VARIOUS PARTS OF THE WORLD FROM CASES OF LEPROMATOUS AND TUBERCULOID LEPROSY MAKE POSSIBLE THEIR ASSIGNMENT TO ONE OF THE THREE GENERA: Corynebacterium, Mycobacterium, or Propionibacterium. One, bacterium 22M, remains unassigned. The combined chemical and enzymatic properties attributed to leprosy bacilli freshly harvested from leprom...
متن کاملLeprosy in children: correlation of clinical, histopathological, bacteriological and immunological parameters.
The study of leprosy in children has indicated an incidence of 10% amongst leprosy patients attending the clinic. The duration of the disease was usually less than 2 years. The expression of leprosy in this group was either a macule and/or a plaque. Classification was, therefore, different and conforms to indeterminate (I), borderline tuberculoid (BT) and borderline (BB) leprosy. Only occasiona...
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متن کامل
Growth characteristics of an acid-fast Mycobacterium isolated from human lepromatous leprosy.
r.ri ssue culture experiments designed to elucidate the affinity of the leprosy bacillus to nerve elements were fir st r eported in October 1958 (' . ). A preliminary note on continuous cultivation of an acid-fast microorgani sm isolated from lepromatous leprosy was published in the same year (' ). The present paper reports in vi fTo studies on the growth pattern of the organism, and also its b...
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ورودعنوان ژورنال:
- Annals of the New York Academy of Sciences
دوره 54 1 شماره
صفحات -
تاریخ انتشار 1951